Antiinflammatory Agents; Chemistry and Pharmacology, Partie 2

acid action activity addition adjuvant administration agents aggregation animals antibody antigen antiinflammatory drugs appears arthritis aspirin assay assessment binding Biochem Biol blood carrageenan caused cells changes chronic clinical collagen complete compounds concentrations connective tissue demonstrated described detected determine disease dose edema effects efficacy enzyme et al evaluation experimental factors function guinea pig half-life human important increase indicates indomethacin induced inflammation inflammatory inhibition injection involved joint laboratory leukocytes levels London lysosomes measured mechanism metabolism metabolites method mg/kg models Nature nonsteroidal normal observed obtained occurs patients Pharmacol phase phenylbutazone plasma platelet possible present Proc produced prostaglandin protein rats reaction reference relatively release reported response rheumatoid salicylate sensitive serum shown skin species steroids studies suggested synthesis Table Ther therapeutic tion tissue toxicity treatment various vitro vivo Whitehouse