Chemistry and Application of H-Phosphonates

Couverture
Elsevier, 25 sept. 2006 - 336 pages
Chemistry and Application of H-Phosphonates is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of diesters of H-phosphonic acid makes them an excellent choice as synthone in a number of practically important reactions.

Phosphonic acid esters are intermediates in the synthesis of important classes of compounds such as alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of each of these compound classes is reviewed in detail.

Alpha-Aminophosphonic acids are an important class of biologically active compounds, which have received an increasing amount of attention because they are considered to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic agents are well documented. Alpha-Hydroxyalkanephosphonates are compounds of significant biological and medicinal applications. Dialkyl epoxyalkylphosphonates are of interest because of their use as intermediates in the synthesis of bioactive substances, and as modifiers of natural and synthetic polymers. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of drugs. Nucleoside H-phosphonates seem to be the most attractive candidates as starting materials in the chemical synthesis of DNA and RNA fragments. The 5’-hydrogen phosphonate-3’-azido-2’,3’-dideoxythimidine is one of the most significant anti-HIV prodrug, which is currently in clinical trials.

Chapters review the synthesis; physical and spectral properties (1H, 13C, 31P and 17O NMR data); characteristic reactions; important classes of compounds based on these esters of H-phosphonic acid; their application as physiologically active substances, flame retardants, catalysts, heat and light stabilizers, lubricants, scale inhibitors, polymer-carriers of drugs; preparation of H-phosphonate diesters and general procedures for conducting the most important reactions.

* provides ideas for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds)* reviews structure, spectra and biological activity of H-phosphonates and their derivatives* examines new areas of application of phosphorus-containing compounds

 

Pages sélectionnées

Table des matières

Methods for Preparation and Physical Properties of HPhosphonates
1
2 Structure and Spectral Characteristics of HPhosphonates
11
3 Reactivity of HPhosphonates
23
4 Important Classes of Compounds
107
5 Application of HPhosphonate Diesters and their Derivatives
253
Subject Index
285
Droits d'auteur

Autres éditions - Tout afficher

Chemistry and Application of H-phosphonates
Kolio Dimov Troev
Aucun aperçu disponible - 2006

Expressions et termes fréquents

1H NMR A. N. Pudovik active addition of dialkyl alcohol aldehydes alkoxy group alkylation amines amino aminophosphonic acids anion aryl Atherton–Todd reaction bisphosphonates carbon atom catalyst CCl4 CH3 CH3 Chem chemical chloride complexes corresponding dialkyl H-phosphonates diesters diesters of H-phosphonic dimethyl H-phosphonate diphenyl H-phosphonate DMTrO doublet drug esters formation glyphosate H-phos H-phosphonate diesters H-phosphonic acid hydrogen hydrolysis hydroxyl hydroxyphosphonate intermediate J(PH Khim method mmol molecular monoalkyl H-phosphonate Nauk SSSR Nifantief NMR spectroscopy nucleophilic nucleoside nucleoside H-phosphonates Obshch obtained OCH3 oxidation oxygen P–C bond P–H group phonate phos phosphate)s phosphite phosphonate phosphorus atom phosphoryl poly(alkylene H-phosphonate)s poly(oxyethylene polymers polyurethane preparation presence proton pyridine reaction mixture reactivity signal sodium solvent substituents Sulfur synthesis Tetrahedron Lett transesterification triethylamine Troev yield

À propos de l'auteur (2006)

Kolio Dimov Troev completed his undergraduate work at Higher Institute of Chemical Technology, Sofia; received his doctorate in the field of organophosphorus chemistry in 1974 from the Institute of Organic Chemistry, Bulgarian Academy of Sciences with Prof. Georgy Borissov; and was awarded the scientific degree “Doctor of Science in 1985 from the Institute of Polymers. In 1988, he became Professor of Chemistry at the same Institute. He has been the founding head of the laboratory “Phosphorus-containing monomers and polymers since 1989. His research interests are the areas of organophosphorus chemistry, especially esters of H-phosphonic acid; aminophosphonates; biodegradable, biocompatible phosphorus-containing polymers; polymer conjugates; drug delivery systems. He has been a visiting professor/lecturer in the USA (Marquette University, Tulane University), Japan (Tokyo Institute of Technology, University of Tokyo, Tohoku University, Tokyo University of Science), and Germany (Duesseldorf University). He is the author of more than 150 papers in this field published in the Phosphorus, Sulfur, Silicon and Related Elements, Heteroatom Chemistry, Journal of American Chemical Society, European Polymer Journal, Polymer, Bioorganic & Medicinal Chemistry, Journal of Medicinal Chemistry, Macromolecular Rapid Communication, Polymer Degradation and Stability, Journal of Polymer Science, Part A: Polymer Chemistry, European Journal of Medicinal Chemistry, Amino Acids, Tetrahedron Letters, Macromolecules, and RSC Advances. He is also the author of two other Elsevier books, Chemistry and Application of H-phosphonates (2006) and Polyphosphoesters: Chemistry and Application (2012). He was a director of the Institute of Polymers, Bulgarian Academy of Sciences from November 2003 to February 2012.

Informations bibliographiques

TitreChemistry and Application of H-Phosphonates
AuteurKolio D. Troev
ÉditeurElsevier, 2006
ISBN008047649X, 9780080476490
Longueur336 pages
  
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