The Biology of Skeletal Metastases

Couverture
Evan T. Keller, Leland W.K. Chung
Springer Science & Business Media, 29 févr. 2004 - 344 pages

Metastasis to bone is a common event in cancer. However, due to the skeleton's unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases.

Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator.

 

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Table des matières

THE BASIC BIOLOGY OF METASTASI
1
CLINICAL ASPECTS OF BONE METASTASES IN PROSTATE CANCER
23
ANIMAL MODELS OF BONE METASTASIS
47
MIP1 ALPHA AND MYELOMA BONE DISEASE
83
TYPE I COLLAGENMEDIATED CHANGES IN GENE EXPRESSION AND FUNCTION OF PROSTATE CANCER CELLS
101
PTHRP AND SKELETAL METATASIS
127
OPG RANKL AND RANK IN CANCER METASTASIS EXPRESSION AND REGULATION
149
MATRIX METALLOPROTEINAES AND BONE METASTASIS
173
ENDOTHELINS IN BONE CANCER METASTASES
197
BISPHOSPHONATE ACTIONS ON BONE AND VISCERAL METASTASES
213
GENE THERAPY FOR PROSTATE CANCER BONE METASTASIS
231
CANCER CELLS HOMING TO BONE THE SIGNIFICANCE OF CHEMOTAXIS AND CELL ADHESION
291
HISTOLOGICAL IMMUNOPHENOTYPIC AND HISTOMORPHOMETRIC CHARACTERIZATION OF PROSTATE CANCER BONE METASTASES
311
Index
341
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