The Biology of Skeletal MetastasesEvan T. Keller, Leland W.K. Chung Springer Science & Business Media, 29 févr. 2004 - 344 pages Metastasis to bone is a common event in cancer. However, due to the skeleton's unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases. Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator. |
Table des matières
THE BASIC BIOLOGY OF METASTASI | 1 |
CLINICAL ASPECTS OF BONE METASTASES IN PROSTATE CANCER | 23 |
ANIMAL MODELS OF BONE METASTASIS | 47 |
MIP1 ALPHA AND MYELOMA BONE DISEASE | 83 |
TYPE I COLLAGENMEDIATED CHANGES IN GENE EXPRESSION AND FUNCTION OF PROSTATE CANCER CELLS | 101 |
PTHRP AND SKELETAL METATASIS | 127 |
OPG RANKL AND RANK IN CANCER METASTASIS EXPRESSION AND REGULATION | 149 |
MATRIX METALLOPROTEINAES AND BONE METASTASIS | 173 |
ENDOTHELINS IN BONE CANCER METASTASES | 197 |
BISPHOSPHONATE ACTIONS ON BONE AND VISCERAL METASTASES | 213 |
GENE THERAPY FOR PROSTATE CANCER BONE METASTASIS | 231 |
CANCER CELLS HOMING TO BONE THE SIGNIFICANCE OF CHEMOTAXIS AND CELL ADHESION | 291 |
HISTOLOGICAL IMMUNOPHENOTYPIC AND HISTOMORPHOMETRIC CHARACTERIZATION OF PROSTATE CANCER BONE METASTASES | 311 |
| 341 | |