Limb RegenerationCambridge University Press, 13 juil. 1996 - 241 pages The complex phenomenon of limb regeneration that occurs in some Amphibia involves unique molecular and cellular mechanisms. When a limb is amputated a new one is produced by the transformation of the remaining adult limb tissues into an embryonic-like cell mass, called the blastema. The blastema has the ability to subsequently redifferentiate into the various tissues that comprise a limb and therefore replace the lost part. Some scientists argue that the same processes that are encountered in normal embryogenesis are reinitiated during regeneration. This is the first book that describes and analyzes the mechanisms of both limb regeneration and patterning by incorporating the information obtained from older experiments with the many new advances in molecular and cellular biology that have occurred in recent years. |
Table des matières
Prologue | 1 |
Capacity of limb regeneration in vertebrates | 7 |
The amputation the early events | 19 |
The beginning of regeneration wound epithelium | 25 |
Dedifferentiation and origin of the blastema | 32 |
4 | 39 |
8 | 45 |
1 | 61 |
Genetics and limb regeneration | 114 |
61 | 123 |
Morphogenetic properties of the blastema | 125 |
The regeneration of positional information | 135 |
Vitamin A and patterning | 154 |
Hox genes and limb regeneration | 182 |
Regenerating versus developing limbs | 188 |
Applications of modern techniques to the field | 195 |
Nerve dependence of regeneration | 67 |
Protein synthesis in the blastema | 81 |
Tissue versus epimorphic regeneration | 94 |
Differentiation of the blastema | 96 |
Postembryonic induction in amphibian limbs | 103 |
Epilogue | 203 |
| 210 | |
| 227 | |
| 237 | |
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Expressions et termes fréquents
9-cis-retinoic acid adult amphibian amphibian limb amputation animals antibody axolotl axolotl limb Biol blastema cells blastema formation blastemata Brockes Bryant carcinogens cartilage cellular CRABP culture denervated developing and regenerating developing limb differentiation digits distal dorsal double posterior effects of retinoic embryonic epimorphic eration experiments explants expression Figure forelimb frog gradient graft growth hindlimb hormone Hox genes humerus implanted indicate induce inhibition intact limb interactions intercalation keratin limb blastema limb bud limb development limb regeneration Maden markers mechanisms Mescher mesenchyme molecular morphogenesis Morphol Muneoka muscle mutant nerve newt newt limb normal Notophthalmus viridescens observed pattern formation positional information positional values protein synthesis proximal proximal-distal axis receptors regenerating limb regeneration blastema regenerative capacity retinoic acid retinoic acid receptor retinoids Rio-Tsonis role salamanders skin stage Stocum structures studies stump supernumerary limbs tail Tassava tion tissues transfected transplantation Triturus Tsonis urodeles ventral vertebrates vitamin wound epithelium Xenopus Zool