Nephrotoxicity, ototoxicity of drugs

acute interstitial nephritis acute renal failure administration amikacin amino acid aminoglycoside antibiotics aminoglycoside nephrotoxicity animals antibiotiques Antimicrob Biochem biopsy brush border céfazoline cellules cephaloglycin cephaloridine cephalosporins cephalothin Chemother Clin clinical coenzyme Q concentration of gentamicin cortex creatinine clearance d'une damage decrease deux dogs dosage dose drug effect enzymes être étude excretion experimental Figure FILLASTRE J.P. francs furosemide genta gentamicin nephrotoxicity glomerular filtration glycoside guinea pig hair cells increased induced inhibition injection INSERM interaction jours kanamycin Kidney Int l'excrétion lesions levels LUFT F.C. lysosomes malades membrane methicillin mg/kg micin mitochondrial neomycin nephro néphrotoxicité nephrotoxicity netilmicin normal observed ont été ototoxicity perilymph pharmacokinetic Pharmacol phosphatase phospholipids protein proximal tubular cells rats renal cortical renal function renal tubular rénale serum creatinine sodium Sous la direction studies Table therapy tissue accumulation tobramycin traitement transport treatment tubular necrosis tubule uptake urinaire urinary urine vitro vivo µg/ml