Textbook of Bone MetastasesClaude Jasmin, Rodolfo Capanna, Lawrence Coia, Robert Coleman, Gerard Saillant John Wiley & Sons, 27 sept. 2005 - 582 pages The epidemiological and clinical importance of bone metastases has long been recognised. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on the patient's quality of life. Bone metastases have generally received insufficient attention because of the difficulty in quantifying them, which has left them outside the scope of therapeutic trials This textbook is the result of the remarkable progress made in the understanding of the molecular and cellular mechanisms involved in osteogenesis and osteolysis, and their development for therapeutic purposes. The treatment of malignant hypercalcaemia has also been revolutionised by the use of bisphosphonates. The Textbook of Bone Metastases presents a broad approach to recent progress in all fields related to bone metastases, ranging from epidemiology to the physiopathology of bone metastases and therapeutics. It provides a better understanding of recent advances and, more importantly, will give clinicians all the information needed to help them in the clinical and therapeutic management of patients with bone metastases. |
Table des matières
Section 2 CLINICAL FEATURES AND ASSESSMENT | 63 |
Section 3 SURGICAL TREATMENT | 133 |
Section 4 LOCAL TREATMENTS | 225 |
Section 5 SYSTEMIC TREATMENTS | 259 |
Section 6 BISPHOSPHONATES | 323 |
Section 7 THE GLOBAL APPROACH | 427 |
Section 8 BONE METASTASES IN SPECIFIC TUMOURS | 469 |
| 555 | |
Autres éditions - Tout afficher
Textbook of Bone Metastases Claude Jasmin,Rodolfo Capanna,Lawrence Coia,Robert Coleman,Gerard Saillant Aucun aperçu disponible - 2005 |
Textbook of Bone Metastases Claude Jasmin,Rodolfo Capanna,Lawrence Coia,Robert Coleman,Gerard Saillant Aucun aperçu disponible - 2005 |
Expressions et termes fréquents
activity adjuvant apoptosis assessment associated biopsy bisphos bisphosphonates bone loss bone marrow bone metastases bone mineral bone pain bone resorption bone scan breast cancer breast cancer patients calcium cancer cells Cancer Res chemotherapy Clin Oncol Clin Orthop clinical clodronate decrease diagnosis dose effects etidronate evaluation femoral femur Figure fixation fractions growth factors hypercalcaemia increased inhibit intravenous involvement long bones lung cancer lymphoma lytic malignant markers of bone median metastatic bone disease metastatic breast cancer metastatic disease multiple myeloma Oncology osteoclast osteolytic osteoporosis pain relief palliative pamidronate pathological fractures patients with bone patients with metastatic phonates placebo postmenopausal primary tumour prostate cancer protein PTHrP radiation therapy radiographs radiotherapy randomised RANKL receptor reconstruction reduced renal cell carcinoma reported resection response rate risk role serum significant skeletal complications skeletal metastases spine surgery surgical survival tamoxifen tion treated treatment trial tumour tumour cells vitro women zoledronic acid