Molecular Approaches to Heart Failure Therapy: With ... 16 TablesSpringer Science & Business Media, 2000 - 357 pages Alterations in excitation-contraction coupling and potential gene thrapy targets in failing human hearts.- Cardiac overexpression of ß-adrenergic receptors.- Genetic approaches to elucidate the regulatory role of phospholamban in the heart-. Manipulation of SERCA2a in the heart by gene transfer-. Changing the cardiac calcium transient: SERCA2 overexpression versus phospholamban inhibition.- Adenovirus-mediated gene transfer of SERCA isoforms.- Overexpression of FKBP12.6 to influenxe SR function.- Adenovirus-mediated myocardial gene therapy.- Adenovirus-mediated transfection of multicellular cardiac preparations.- Myocardial-specific gene delivery.- Transfection studies using a new cardiac 3D gel system.- Cellular mechanisms of cardiac arrhythmias - do they play a role in heart failure?.- Potassium channel overexpression.- Mechanisms and relevance of apoptosis.- Strategies to prevent apoptosis.- Neurohumoral modulation of metalloproeinases in cardiac failure: impact on remodeling.- Oxidative stress in heart failure.- Modulation of cardiac function by essential myosin light chains in health and disease.- Mycardial infarction, infarct repair, and strategies for muscle regeneration.- Cardiomyocytes can induce rhythmic contraction of skeletal muscle cells. Potenial use for infarct repair.- Strategies to identify cardimyocyte xell cycle regulatory genes. |
Table des matières
Alterations in excitationcontraction coupling and potential gene therapy targets in failing human hearts | 5 |
Cardiac overexpression of ßadrenergic receptors | 24 |
Genetic approaches to elucidate the regulatory role of phospholamban in the heart | 37 |
Manipulation of SERCA2a in the heart by gene transfer | 49 |
Changing the cardiac calcium transient SERCA2 overexpression versus phospholamban inhibition | 65 |
Adenovirusmediated gene transfer of SERCA isoforms | 72 |
Overexpression of FKBP126 to influence SR function | 85 |
Adenovirusmediated myocardial gene therapy | 96 |
Potassium channel overexpression | 176 |
Mechanisms and relevance of apoptosis | 193 |
Strategies to prevent apoptosis | 228 |
Neurohumoral modulation of metalloproteinases in cardiac failure impact on remodeling | 243 |
Oxidative stress in heart failure | 258 |
Modulation of cardiac function by essential myosin light chains in health and disease | 281 |
Myocardial infarction infarct repair and strategies for muscle regeneration | 294 |
Cardiomyocytes can induce rhythmic contraction of skeletal muscle cells Potential use for infarct repair | 312 |
Adenovirusmediated transfection of multicellular cardiac preparations | 108 |
Myocardialspecific gene delivery | 122 |
Transfection studies using a new cardiac 3D gel system | 140 |
Cellular mechanisms of cardiac arrhythmias do they play a role in heart failure? | 153 |
Strategies to identify cardiomyocyte cell cycle regulatory genes | 329 |
349 | |
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Expressions et termes fréquents
Acad Sci USA action potential activity adenoviral vectors adenovirus adenovirus-mediated adult alterations anti-apoptotic apoptosis apoptotic ATPase atrial Biol Chem Ca² Ca2+-ATPase cadherin calcium cardiac myocytes cardiomyocytes caspase cell death cellular channel Circ Circ Res Circulation Clin Invest connexin43 culture cytes cytochrome cytosolic decrease diastolic effects EHTs failing heart failing human hearts failing myocyte gene expression gene transfer graft heart failure human myocardium human ventricular hypertrophy increased induced infarction infection inhibition inhibitor intracellular ischemia ischemic isoforms isolated isoproterenol levels mechanisms membrane mitochondrial Mol Cell Cardiol molecular mutant myocardial myocardial infarction myocardium myosin myotubes Natl Acad Sci neonatal non-failing overexpression oxidative stress pathway patients phospholamban phosphorylation Physiol Proc Natl Acad rabbit recombinant regulation release role ryanodine ryanodine receptor sarcoplasmic reticulum SERCA SERCA2a signaling skeletal muscle ẞ-adrenergic stimulation studies target tion tissue transfection transgenic transgenic mice ventricle ventricular myocytes virus vitro vivo wild-type