The Dog and Its Genome

Couverture
Elaine A. Ostrander, Urs Giger, Lindblad-Toh Kerstin
CSHL Press, 3 avr. 2007 - 584 pages
Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twentyfive chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.
 

Table des matières

History and Applications
1
2 The Kennel Club and the Early Historyof Dog Shows and Breed Clubs
19
3 American Breed Clubs andHealth Initiatives
31
4 Morphological Variation in the Dog
47
Morphological Loci in thePortuguese Water Dog Population
67
Are TheyCoupled at the Genome Level?
81
7 From Wild Wolf to Domestic Dog
95
8 mtDNA Studies of the Originof Dogs
119
Searchingfor Unique Phenotypes and Genesin the Dog Model of InheritedRetinal Degeneration
291
17 Copper Toxicosis inBedlington Terriers
327
18 Cystinuria
349
19 Molecular Genetics of DilatedCardiomyopathy
365
20 Sex Chromosomes SexualDevelopment and Sex Reversalin the Dog
383
Strategies for CanineHip Dysplasia
407
22 Breedspecific CanineLymphoproliferative Diseases
439
23 Cancer Biology in Dogs
451

The PhyDo Project
141
10 Karyotype and ChromosomalOrganization
159
Sequence Evolution and Haplotype Structure
179
12 SINEs of Canine Genomic Diversity
209
13 The Dog Olfactory and VomeronasalReceptor Repertoires
221
14 The Canine MajorHistocompatibility Complex
233
15 Breedspecific Hereditary Diseasesand Genetic Screening
249
24 Gene Therapy for MetabolicInherited Diseases in Dogs
473
Humanlike Social Skills in Dogs AreHeritable and Derived
497
What CanDogs and Silver Foxes Tell Usabout Each Other?
515
AKC Recognized Dog Breeds
539
Index
567
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À propos de l'auteur (2007)

Elaine Ann Ostrander is an American geneticist at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in Bethesda, Maryland.

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