Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic OutcomesAddressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is |
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Table des matières
| 1 | |
Chapter 2 In VitroIn Vivo Correlations of | 15 |
Chapter 3 In VitroIn Vivo Correlations of | 53 |
Chapter 4 Metabolic Processes at Injection | 80 |
Chapter 5 Local Tissue Responses to Polymer | 106 |
Chapter 6 Engineering as a Means to Improve | 129 |
Chapter 7 Ophthalmic Delivery of Protein and | 163 |
Chapter 8 Pharmacokinetic and Pharmacodynamic | 173 |
Chapter 9 Oral Delivery of Protein and Peptide | 192 |
Chapter 10 Drug Interaction Studies of Therapeutic | 207 |
Chapter 11 Intersection of Pharmacogenomics with | 225 |
Back Cover | 251 |
Autres éditions - Tout afficher
Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes Randall J. Mrsny,Ann Daugherty Aucun aperçu disponible - 2009 |
Expressions et termes fréquents
absorption Acad Sci U S A acid activity administration albumin angiogenesis antigen assays associated binding affinity bioavailability Biol Chem biological biomaterial blood cancer cells cellular clearance clinical complex conjugates correlation cytokines domain dose drug delivery effect efficacy endogenous enhanced enzymes erythropoietin etanercept extracellular FBGCs FC fusions FcRn fibroblast growth factor fibronectin formulation G-CSF gene half-life heparan sulfate heparin HSPG immunogenicity Immunol implant increased inflammatory inhibition insulin insulin aspart interactions intranasal IVIVC macrophages matrix mechanisms metabolism mice modulation molecular molecules monoclonal antibodies nasal Natl Acad Sci neutrophils oral pathways patients PEGylated peptide peptide drugs peptide therapeutics permeation Pharm pharmacodynamic pharmacokinetics plasma PLGA potential Proc Natl Acad proteases protein protein and peptide protein drugs protein or peptide rats release response SC injection SC space serum studies surface target therapeutic proteins therapy tissue treatment tumor uptake VEGF vitro vivo
Informations bibliographiques
| Titre | Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes Volume 202 de Drugs and the Pharmaceutical Sciences |
| Rédacteurs | Randall J. Mrsny, Ann Daugherty |
| Édition | illustrée |
| Éditeur | CRC Press, 2009 |
| ISBN | 1420078070, 9781420078077 |
| Longueur | 288 pages |
| Exporter la citation | BiBTeX EndNote RefMan |