Biology of the Sialic AcidsA. Rosenberg Springer Science & Business Media, 31 juil. 1995 - 378 pages Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables. |
Table des matières
The Beginnings of Sialic Acid | 1 |
3 Scaling the Sialic Acid Structure | 2 |
4 How Sialobiology Began | 4 |
Biochemistry and Role of Sialic Acids | 7 |
2 Occurrence of Sialic Acids | 12 |
3 Sialic Acid Analysis | 16 |
4 Enzymatic Modifications of Sialic Acids | 21 |
42 DeOAcetylation of Sialic Acids | 22 |
Cellular Biology of Gangliosides | 197 |
2 Structure and Metabolism of Gangliosides | 198 |
3 Physicochemical Properties of Gangliosides | 210 |
4 Species Tissue and Cellular Localization of Gangliosides | 214 |
42 Gangliosides in Extraneural Tissues | 220 |
5 Effects of Exogenous Gangliosides on Differentiation of Neurons and Leukocytes | 222 |
52 Effects of Gangliosides on Leukocyte Differentiation | 226 |
6 Gangliosides as Receptors for Bacteria Viruses and Bacterial Toxins | 227 |
43 OMethylation of Sialic Acids | 23 |
44 NAcetylHydroxylation of Static Acids | 24 |
5 Relationship and Evolutionary Distribution of Microbial Sialidases | 31 |
6 Sialic AcidDependent Receptors and Their Ligands | 36 |
62 Selectins | 39 |
63 CD22 | 43 |
64 Sialoadhesin | 44 |
65 Other Mammalian Sialic AcidDependent Receptors | 45 |
67 Modifications of Sialic Acids | 48 |
References | 49 |
Biological Specificity of Sialyltransferases | 69 |
2 Sialyltransferases Catalyzing Sialooligosaccharides and Sialoglycoprotein Biosynthesis | 71 |
3 Sialyltransferases Catalyzing Sialoglycolipid Biosynthesis | 73 |
32 LactoFamily Glycolipids | 77 |
4 Sialyltransferases Catalyzing Mucin Biosynthesis | 79 |
6 Cloning of α23 Sialyltransferases | 80 |
7 Cloning of α26 Sialyltransferases | 82 |
8 Cloning of α28 Sialyltransferases | 83 |
9 Modulation of Sialyltransferases in Developing Tissues | 84 |
11 Perspectives | 85 |
References | 86 |
Sialobiology and the Polysialic Acid Glycotope Occurrence Structure Function Synthesis and Glycopathology | 95 |
2 Natural Occurrence and Structure of Polysialic AcidContaining Glycoconjugates | 97 |
22 Eukaryotes | 99 |
3 Function of Polysialylation | 107 |
31 Bacterial Pathogenicity | 108 |
33 Sea Urchin Embryogenesis | 109 |
34 Neurobiology | 110 |
35 Tumor Metastasis | 112 |
4 Biosynthesis of the Polysialic Acid Glycotopes | 114 |
42 Rainbow Trout Egg Polysialoglycoproteins | 122 |
43 Sea Urchin Embryo | 127 |
44 Fetal Rat and Embryonic Chick Brains | 128 |
5 Identification of Polysialic Acid and OligoPoly KDN Structures | 129 |
Specific Molecular Probe to Detect and Structurally Modify α28Linked Polysialic Acid Chains | 130 |
53 Discovery and Use of a New Type of Sialidase KDNase to Confirm the Identification of KDNContaining Glycoconjugates | 131 |
6 Concluding Remarks and Future Directions | 132 |
References | 133 |
Biochemistry and Oncology of Sialoglycoproteins | 145 |
2 Classification and Nomenclature | 146 |
31 AsnLinked Saccharides | 147 |
32 SerThrLinked Saccharides | 151 |
33 Polylactosaminoglycans | 154 |
4 Protein Core of OLinked Sialoglycoproteins | 155 |
5 Biosynthesis of Sialoglycoproteins | 161 |
52 Biosynthesis of Glycoproteins Containing AsnLinked Sugar Chains | 162 |
53 Biosynthesis of Glycoproteins Containing SerThrLinked Sugar Chains | 165 |
54 Biosynthesis of Polylactosaminoglycan Chains | 168 |
61 MalignancyAssociated Alterations in NGlycosylated Sialoglycoproteins | 169 |
62 MalignancyAssociated Alterations in OGlycosylated Sialoglycoproteins | 173 |
References | 184 |
7 Tools Useful for the Analysis of Ganglioside Functions | 229 |
References | 230 |
Role of Gangliosides in Transmembrane Signaling and Cell Recognition | 243 |
2 Role of GM3 Ganglioside and Its Immediate Catabolite as Modulators of Transmembrane Signaling | 244 |
3 Role of Other GSLs as Modulators of Receptor Function | 248 |
32 Sialosylparagloboside SPG as a Specific Modulator of the Insulin Receptor | 249 |
5 Direct Involvement of Gangliosides in CellCell Adhesion | 252 |
52 Direct Involvement of GM3 in Cell Adhesion | 253 |
6 Conclusions | 255 |
62 Mediation of CellCell or CellSubstratum Interaction | 256 |
Biochemistry and Function of Sialidases | 261 |
11 Substrates | 262 |
12 Sialidase Assay | 265 |
2 Viral Sialidases | 266 |
22 Properties | 267 |
23 Structure | 268 |
24 Biological Function | 270 |
31 Purification | 271 |
33 Structure | 273 |
34 Biological Function | 275 |
5 Mammalian Sialidases | 277 |
51 Lysosomal Sialidases | 278 |
52 Plasma MembraneBound Sialidase | 285 |
53 Cytosolic Sialidase | 289 |
References | 296 |
Sialic Acid as Receptor Determinant of Ortho and Paramyxoviruses | 315 |
2 ReceptorBinding Proteins | 316 |
22 The HEF Protein of Influenza C Virus | 318 |
23 The HN Protein of Paramyxoviruses | 320 |
32 Sialate 9OAcetylesterase | 325 |
41 Receptor Determinant Sialic Acid | 326 |
42 Receptor Molecules Glycoproteins Gangliosides | 327 |
5 Role of Sialic Acid in Virus Replication | 329 |
53 Spread of Infection | 330 |
References | 331 |
Sialic Acid in Biochemical Pathology | 337 |
2 Summary | 338 |
3 Diseases Related to Defective Sialic Acid Transport | 340 |
4 Diseases Related to Defective Catabolism of Sialic AcidContaining Compounds | 341 |
42 Gangliosidoses | 343 |
43 Galactosialidosis Protective Protein Deficiency | 353 |
5 CarbohydrateDeficient Glycoprotein Syndrome | 355 |
References | 356 |
Neurite Loss Caused by Ganglioside Undersialylation | 363 |
2 Ganglioside Sialylation as a Key to Neuritogenesis | 364 |
3 Ionic Blocking of GangliosideDependent Neuritogenesis | 366 |
4 Ganglioside Undersialylation in the Fetal Alcohol Syndrome | 368 |
371 | |
373 | |
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Expressions et termes fréquents
Acad amino acids antigen B-galactosidase bacterial Basu binding Biochem Biochemistry Biol Biophys biosynthesis bovine Cancer carbohydrate carcinoma catalyzed cDNA cell line cell surface ceramide characterization Chem cloning Clostridium coli K1 containing Corfield cytosolic differentiation disease embryonic enzyme erythrocytes Escherichia coli expression function GalNAc gangliosides gangliosidosis gene genetic glycoconjugates glycolipids glycoproteins glycosphingolipids glycosylation glycosyltransferases Golgi GQ1b Hakomori human influenza virus inhibited Inoue interaction isolated ligands linkage lysosomal mammalian melanoma Miyagi molecular monoclonal antibodies mouse MUC1 mucin mutations N-CAM Natl Neu5Gc NeuAca neuraminidase neurite neurons O-acetylated O-glycosylated O-linked oligosaccharides P-selectin Paulson peptide plasma membrane polySia chains polysialic acid polysialylated Proc protein purified rat brain rat liver receptor Roggentin role Rosenberg saccharides Saito Schauer Schengrund selectins sequence sialic acid sialic acid residues sialidase sialidase activity sialoglycoproteins sialyl sialyltransferase specific structure studies substrate sugar chains Suzuki synthesis Tay-Sachs disease tissues transferase Troy tumor Varki Vimr viral viruses
Fréquemment cités
Page 336 - Wilson, IA, Skehel, JJ, and Wiley, DC (1981). Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.