Biology of the Sialic Acids

Couverture
A. Rosenberg
Springer Science & Business Media, 31 juil. 1995 - 378 pages
Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.
 

Pages sélectionnées

Table des matières

The Beginnings of Sialic Acid
1
3 Scaling the Sialic Acid Structure
2
4 How Sialobiology Began
4
Biochemistry and Role of Sialic Acids
7
2 Occurrence of Sialic Acids
12
3 Sialic Acid Analysis
16
4 Enzymatic Modifications of Sialic Acids
21
42 DeOAcetylation of Sialic Acids
22
Cellular Biology of Gangliosides
197
2 Structure and Metabolism of Gangliosides
198
3 Physicochemical Properties of Gangliosides
210
4 Species Tissue and Cellular Localization of Gangliosides
214
42 Gangliosides in Extraneural Tissues
220
5 Effects of Exogenous Gangliosides on Differentiation of Neurons and Leukocytes
222
52 Effects of Gangliosides on Leukocyte Differentiation
226
6 Gangliosides as Receptors for Bacteria Viruses and Bacterial Toxins
227

43 OMethylation of Sialic Acids
23
44 NAcetylHydroxylation of Static Acids
24
5 Relationship and Evolutionary Distribution of Microbial Sialidases
31
6 Sialic AcidDependent Receptors and Their Ligands
36
62 Selectins
39
63 CD22
43
64 Sialoadhesin
44
65 Other Mammalian Sialic AcidDependent Receptors
45
67 Modifications of Sialic Acids
48
References
49
Biological Specificity of Sialyltransferases
69
2 Sialyltransferases Catalyzing Sialooligosaccharides and Sialoglycoprotein Biosynthesis
71
3 Sialyltransferases Catalyzing Sialoglycolipid Biosynthesis
73
32 LactoFamily Glycolipids
77
4 Sialyltransferases Catalyzing Mucin Biosynthesis
79
6 Cloning of α23 Sialyltransferases
80
7 Cloning of α26 Sialyltransferases
82
8 Cloning of α28 Sialyltransferases
83
9 Modulation of Sialyltransferases in Developing Tissues
84
11 Perspectives
85
References
86
Sialobiology and the Polysialic Acid Glycotope Occurrence Structure Function Synthesis and Glycopathology
95
2 Natural Occurrence and Structure of Polysialic AcidContaining Glycoconjugates
97
22 Eukaryotes
99
3 Function of Polysialylation
107
31 Bacterial Pathogenicity
108
33 Sea Urchin Embryogenesis
109
34 Neurobiology
110
35 Tumor Metastasis
112
4 Biosynthesis of the Polysialic Acid Glycotopes
114
42 Rainbow Trout Egg Polysialoglycoproteins
122
43 Sea Urchin Embryo
127
44 Fetal Rat and Embryonic Chick Brains
128
5 Identification of Polysialic Acid and OligoPoly KDN Structures
129
Specific Molecular Probe to Detect and Structurally Modify α28Linked Polysialic Acid Chains
130
53 Discovery and Use of a New Type of Sialidase KDNase to Confirm the Identification of KDNContaining Glycoconjugates
131
6 Concluding Remarks and Future Directions
132
References
133
Biochemistry and Oncology of Sialoglycoproteins
145
2 Classification and Nomenclature
146
31 AsnLinked Saccharides
147
32 SerThrLinked Saccharides
151
33 Polylactosaminoglycans
154
4 Protein Core of OLinked Sialoglycoproteins
155
5 Biosynthesis of Sialoglycoproteins
161
52 Biosynthesis of Glycoproteins Containing AsnLinked Sugar Chains
162
53 Biosynthesis of Glycoproteins Containing SerThrLinked Sugar Chains
165
54 Biosynthesis of Polylactosaminoglycan Chains
168
61 MalignancyAssociated Alterations in NGlycosylated Sialoglycoproteins
169
62 MalignancyAssociated Alterations in OGlycosylated Sialoglycoproteins
173
References
184
7 Tools Useful for the Analysis of Ganglioside Functions
229
References
230
Role of Gangliosides in Transmembrane Signaling and Cell Recognition
243
2 Role of GM3 Ganglioside and Its Immediate Catabolite as Modulators of Transmembrane Signaling
244
3 Role of Other GSLs as Modulators of Receptor Function
248
32 Sialosylparagloboside SPG as a Specific Modulator of the Insulin Receptor
249
5 Direct Involvement of Gangliosides in CellCell Adhesion
252
52 Direct Involvement of GM3 in Cell Adhesion
253
6 Conclusions
255
62 Mediation of CellCell or CellSubstratum Interaction
256
Biochemistry and Function of Sialidases
261
11 Substrates
262
12 Sialidase Assay
265
2 Viral Sialidases
266
22 Properties
267
23 Structure
268
24 Biological Function
270
31 Purification
271
33 Structure
273
34 Biological Function
275
5 Mammalian Sialidases
277
51 Lysosomal Sialidases
278
52 Plasma MembraneBound Sialidase
285
53 Cytosolic Sialidase
289
References
296
Sialic Acid as Receptor Determinant of Ortho and Paramyxoviruses
315
2 ReceptorBinding Proteins
316
22 The HEF Protein of Influenza C Virus
318
23 The HN Protein of Paramyxoviruses
320
32 Sialate 9OAcetylesterase
325
41 Receptor Determinant Sialic Acid
326
42 Receptor Molecules Glycoproteins Gangliosides
327
5 Role of Sialic Acid in Virus Replication
329
53 Spread of Infection
330
References
331
Sialic Acid in Biochemical Pathology
337
2 Summary
338
3 Diseases Related to Defective Sialic Acid Transport
340
4 Diseases Related to Defective Catabolism of Sialic AcidContaining Compounds
341
42 Gangliosidoses
343
43 Galactosialidosis Protective Protein Deficiency
353
5 CarbohydrateDeficient Glycoprotein Syndrome
355
References
356
Neurite Loss Caused by Ganglioside Undersialylation
363
2 Ganglioside Sialylation as a Key to Neuritogenesis
364
3 Ionic Blocking of GangliosideDependent Neuritogenesis
366
4 Ganglioside Undersialylation in the Fetal Alcohol Syndrome
368
References
371
Index
373
Droits d'auteur

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Expressions et termes fréquents

Fréquemment cités

Page 336 - Wilson, IA, Skehel, JJ, and Wiley, DC (1981). Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.

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