Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner EarRaymond Romand, Isabel Varela-Nieto Elsevier, 15 déc. 2003 - 490 pages Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike. * Scores of high-quality, full- color figures* Detailed schemes on the structure and timing of ear development* Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology |
Table des matières
| 1 | |
Chapter 2 Use of Mouse Genetics for Studying Inner Ear Development | 45 |
Chapter 3 Formation of the Outer and Middle Ear Molecular Mechanisms | 85 |
Chapter 4 Molecular Basis of Inner Ear Induction | 115 |
A Role for HomeodomainContaining Transcription Factors and Signaling Molecules | 151 |
Interactions between Intrinsic and Extrinsic Signals | 177 |
Chapter 7 Neurotrophic Factors during Inner Ear Development | 207 |
Chapter 8 FGF Signaling in Ear Development and Innervation | 225 |
Chapter 10 Hair Cell Development in Higher Vertebrates | 293 |
Chapter 11 Cell Adhesion Molecules during Inner Ear and Hair Cell Development Including Notch and Its Ligands | 321 |
Chapter 12 Genes Controlling the Development of the Zebrafish Inner Ear and Hair Cells | 357 |
Chapter 13 Functional Development of Hair Cells | 389 |
Chapter 14 The Cell Cycle and the Development and Regeneration of Hair Cells | 449 |
| 467 | |
Contents of Previous Volumes | 483 |
Color Plate Section | 491 |
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Expressions et termes fréquents
activity adhesion molecules auditory aVected BDNF Biol branchial arch bundle cadherin cell cycle cell fate cellular channels chick cochlea defects developmental diVerent dlx3b Dlx5 domain Drosophila duct ear induction early ectoderm ectopic embryos epithelia epithelium eVects expression patterns Fekete FGF signaling Fgf3 and Fgf8 Fgfr1 fibroblast growth factor formation Fritzsch function ganglion gene expression Genet hair cell diVerentiation Hes1 hindbrain homeobox inner ear inner ear development inner hair cells interactions ligand mammalian markers Math1 Mech membrane mesenchyme middle ear molecular morphogenesis mutant mice mutants myosin VIIa neural crest Neurosci neurotrophin normal Notch signaling null mutant organ of Corti otic epithelium otic placode induction otic vesicle otocyst outer hair cells pathway Pax2 pax8 phenotype Pirvola placode postnatal proliferation protein region regulate retinoic acid retinoid role semicircular canals sensory epithelium sensory neurons specific stage stereocilia suggest supporting cells target tissue transcription factors transduction vertebrate vestibular zebrafish Zheng