Bacterial BiofilmsTony Romeo Springer Science & Business Media, 26 févr. 2008 - 294 pages Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth. |
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Expressions et termes fréquents
ability acid activity addition adhesin adhesion aeruginosa biofilms amphotericin antibiotic antimicrobial agents appears attachment aureus bacterial biofilms Bacteriol binding biofilm development biofilm formation bladder catheters cause cells Chemother colonization concentrations Costerton culture curli dependent detachment effect encoding environmental Escherichia coli et al expression extracellular factors fimbriae flea function gene expression genes genetic glucose growth host Immun important increased indicated induced infections influence inhibit initial interactions involved isolates Kolter leads levels matrix mechanisms membrane microbial Mol Microbiol molecular molecules motility mutants natural observed organisms pathway patients persisters pestis phase phenotype planktonic polysaccharide population production promoter protein Pseudomonas aeruginosa quorum sensing recent regulation regulatory repression resistance response role showed shown signal species Staphylococcus epidermidis strains structure studies suggesting surface synthesis tion transcription treatment UPEC Vibrio cholerae virulence vitro Yersinia
Fréquemment cités
Page iii - Tasuku Honjo Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan...