Metals, Fertility, and Reproductive ToxicityEnvironmental endocrine disruptors have been at the heart of discussions about chemicals and their effects on fertility, but the focus has been on organic compounds and the role of metals has been largely overlooked - until now. Taking an organ-system-based approach, Metals, Fertility, and Reproductive Toxicity examines the effects of metals found in the everyday environment on fertility rates in humans and animal populations. This volume summarizes and evaluates the literature in the area of metal effects on fertility and reproduction in humans, laboratory animals, and wildlife. International experts have contributed chapters that explore how the ovary, testes, uterine system, and neuroendocrine system, among others, respond to metal exposure. Reviewing both current knowledge and cutting edge data, the chapters focus on either a particular metal or a particular population. A massive amount of data on this subject has been generated, summarized, and reviewed over the years. While there are many books available on metals toxicity and on reproductive toxicity, no current book explores both in the same volume. Culling information from throughout the literature, Metals, Fertility, and Reproductive Toxicity supplies an in-depth look at the role of metals in endocrine disruption and the spectrum of mechanisms involving metals that can influence reproduction. |
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Table des matières
| 9 | |
| 19 | |
| 65 | |
Intrauterine and Reproductive Toxicity of Nutritionally | 93 |
Lead Exposure and Its Effects on the Reproductive | 117 |
Impact of Metals on Ovarian Function | 155 |
Epidemiological and Occupational Studies of Metals | 175 |
Use of Metal Reproductive Toxicity Data in Selecting | 213 |
Index | 245 |
Autres éditions - Tout afficher
Expressions et termes fréquents
administration adverse effects aluminum arsenic assessment birth blood body weight Butyltin BW/day cadmium cells chloride chromium cleft palate concentrations copper Corbella DBTCI defects developmental toxicity Domingo Dosage dose drinking water ecological effects of lead embryos endpoints Environ Health Environmental epididymis estradiol estrogen evaluated exposed fertility fetal weight fetuses follicles Gavage gestation day hormone human imposex increased induced infertility injection Lead Acetate lead exposure Llobet male reproductive malformations manganese maternal toxicity mating mercury mg Pb/L mg/kg and higher mg/kg/day mg/L mice motility mouse nickel NOAEL occupational offspring oral ovarian ovary ovulation Pb Ac postimplantation loss postnatal potential pregnancy Gavage progesterone pups reduced reported Reprod reproductive effects reproductive toxicity semen parameters semen quality seminal serum significant Sokol species sperm count spermatogenesis spermatozoa TBTC1 TBTCI teratogenic Teratology testes testicular testosterone toxic effects Toxicol Toxicology tributyltin uranium uterine vanadium vitro welders Wistar rat zinc
Fréquemment cités
Page 58 - Epstein, SS, Arnold, E., Andrea, J., Bass, W., and Bishop, Y.: Detection of chemical mutagens by the dominant lethal assay in the mouse.
Page 21 - Placental element levels in relation to fetal development for obstetrically "normal" births: a study of 37 elements. Evidence for effects of cadmium, lead and zinc on fetal growth, and for smoking as a source of cadmium.
Page 243 - Reiter, LW, Anderson, GE, Laskey, JW and Cahill, DF (1975). Developmental and Behavioral Changes in the Rat During Chronic Exposure to Lead.
Page 172 - Richards JS, Jahnsen T, Hedin L, Lifka J, Ratoosh S, Durica JM Goldring NB 1987.
Page 210 - Occupation of father at time of birth of children dying of malignant diseases.
Page 19 - The relationship between cadmium, zinc, and birth weight in pregnant women who smoke. Am J Obstet Gynecol 1987:157:1247-51.
Page 242 - Chronic low-level lead toxicity in the rat: II. Effects on postnatal physical and behavioral development. Toxicol. Appl. Pharmacol.

