Peroxisome Proliferators: Unique Inducers of Drug-Metabolizing EnzymesCRC Press, 12 juil. 1994 - 200 pages Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial, and regulatory areas of pharmacology and toxicology. This monograph, for the first time, has brought together researchers who deal specifically with drug-metabolizing enzymes and peroxisome proliferators. It contains an up-to-date review of peroxisome proliferation, with detailed tables on the 100 known peroxisome proliferators and studies on their hepatocarcinogic capacity. It provides current material from 12 different laboratories doing cutting-edge research on the effect of peroxisome proliferators on drug-metabolizing enzymes.The book covers the response of cytochrome P450s, UDP-glucuronosyltransferases, epoxide hydrolases, glutathione S-transferase, DT-diaphorase, and other enzymes. |
Table des matières
An Overview | 1 |
Induction of Cytochromes P450 by Peroxisome Proliferators | 29 |
Effect of Peroxisome Proliferators on Microsomal P450 Reactions | 37 |
33 | 52 |
Peroxisome Proliferator Acitvated ReceptorMediated Induction of P450 | 63 |
UDPGlucuronosyltransferases and Peroxisome proliferators | 79 |
The Response of Soluble Epoxide Hydrolase and Other Hydrolytic | 97 |
Peroxisome Proliferation and the Subcellular Localization of Soluble | 113 |
Responses of Epoxide Hydrolases Glutathione STransferases DTDiaphorase | 123 |
Antioxidant Enzyme Activity Modulation by Peroxisome Proliferators | 141 |
123 | 149 |
Induction of DrugMetabolizing Enzymes by ShortIntermediateTerm | 161 |
Drug Metabolizing Enzymes as Part of the Unique Phenotypic Properties | 175 |
Index | 185 |
Expressions et termes fréquents
acid w-hydroxylase Acta acyl-CoA oxidase bilirubin bilirubin UGT binding Biochem Biophys Carcinogenesis carcinogens carnitine catalyze cDNA Chem ciprofibrate clofibrate-treated clofibric acid cloning compounds CYP4A cytochrome P450 cytochrome P450 4A1 cytosolic cytosolic epoxide hydrolase decrease DEHP DePierre di(2-ethylhexyl)phthalate dicarboxylic acids drug-metabolizing enzymes DT-diaphorase effects of peroxisome enzymes expression fatty acid fatty acyl-CoA fractions gene Gibson glucuronidation glutathione S-transferase GPX activity Hammock hepatic catalase activity hepatic peroxisome proliferation hepatocytes human hydroxylation hypolipidemic agents hypolipidemic drugs increased induction of hepatic induction of peroxisomal inhibition kidney Kusunose laurate lauric acid levels lipid liver microsomes liver peroxisomes Magdalou male mechanism metabolism mice microsomal epoxide hydrolase mitochondrial molecular Moody mouse liver mPPAR mRNA nafenopin Natl oxidation perfluorodecanoic acid peroxide peroxisomal ẞ-oxidation peroxisome proliferators Pharmacol PPAR prostaglandin protein rabbit rat liver Reddy regulation response sEH activity sequence soluble epoxide hydrolase specific studies subcellular substrate Toxicol transcription tumors UDP-glucuronosyltransferase vitro xenobiotics