A Practical Guide to Assay Development and High-Throughput Screening in Drug DiscoveryThe development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P |
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Table des matières
| 1 | |
Chapter 2 FluorescenceBased Biochemical Protease Assay Formats | 25 |
Chapter 3 Assay Development for Nuclear Hormone Receptors | 49 |
Chapter 4 Assay Development for G ProteinCoupled Receptors and Ion Channels | 59 |
Chapter 5 Assay Development for Heat Shock Proteins | 83 |
Chapter 6 Assay Development for Cell Viability and Apoptosis for HighThroughput Screening | 99 |
Chapter 7 Assay Development for Antimicrobial Drug Discovery | 123 |
Chapter 8 ImageBased High Content Screening | 143 |
Chapter 10 Assay Development Using Primary and PrimaryLike Cells | 169 |
Chapter 11 Screening Automation | 183 |
Chapter 12 Compound Library Management | 193 |
Chapter 13 Unique Discovery Aspects of Utilizing Botanical Sources | 213 |
Chapter 14 Screening Informatics | 233 |
| 265 | |
Back cover | 279 |
Chapter 9 Application of RNA Interference in Drug Discovery | 157 |
Autres éditions - Tout afficher
A Practical Guide to Assay Development and High-Throughput Screening in Drug ... Taosheng Chen Aucun aperçu disponible - 2009 |
A Practical Guide to Assay Development and High-Throughput Screening in Drug ... Taosheng Chen Aucun aperçu disponible - 2019 |
Expressions et termes fréquents
acid activity added addition allow analysis applications approach assay assay development automated binding Biochem biological cell lines cell-based changes channel Chem chemical components compound compound management concentration containing culture cytoplasm dependent described detection determined dispensing DMSO drug discovery effects enzyme et al example experiments expression factors Figure fluorescence format functional gene high-throughput screening hits human identify important increase incubation informatics inhibition inhibitors integrated interaction kinase labeled lead libraries ligand liquid measure methods molecular molecules natural product needed operational optimization peptide performance plate possible potential primary cells protease protein protocol range reader readout reagents receptor reduce reporter RNAi samples screening selection sensitivity sequence signal solution specific standard step structure studies substrate target tion transfer types usually
Informations bibliographiques
| Titre | A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery Critical Reviews in Combinatorial Chemistry |
| Auteur | Taosheng Chen |
| Édition | illustrée |
| Éditeur | CRC Press, 2009 |
| ISBN | 1420070517, 9781420070514 |
| Longueur | 291 pages |
| Exporter la citation | BiBTeX EndNote RefMan |