A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

CRC Press, 21 déc. 2009 - 291 pages
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The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P

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Table des matières

Chapter 1 Assay Development for Protein Kinases and Phosphatases
Chapter 2 FluorescenceBased Biochemical Protease Assay Formats
Chapter 3 Assay Development for Nuclear Hormone Receptors
Chapter 4 Assay Development for G ProteinCoupled Receptors and Ion Channels
Chapter 5 Assay Development for Heat Shock Proteins
Chapter 6 Assay Development for Cell Viability and Apoptosis for HighThroughput Screening
Chapter 7 Assay Development for Antimicrobial Drug Discovery
Chapter 8 ImageBased High Content Screening
Chapter 10 Assay Development Using Primary and PrimaryLike Cells
Chapter 11 Screening Automation
Chapter 12 Compound Library Management
Chapter 13 Unique Discovery Aspects of Utilizing Botanical Sources
Chapter 14 Screening Informatics
Back cover
Droits d'auteur

Chapter 9 Application of RNA Interference in Drug Discovery

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À propos de l'auteur (2009)

Taosheng Chen earned a BS in biophysics and an MS in molecular cell biology from Fudan University in Shanghai, China. He received his PhD in cell and molecular biology from the University of Vermont at Burlington. Dr. Chen joined the faculty of the Department of Chemical Biology and Therapeutics and became director of the HTS Center at the St. Jude Children's Research Hospital in Memphis in 2006. His laboratory focuses on studying the regulation of transcription factors and their implications in drug metabolism and drug resistance as well as in pediatric cancers. Dr. Chen has authored more than 20 peer-reviewed articles in the areas of cancer biology, drug metabolism, signal transduction, and drug discovery technology.

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