Drug Discovery and Development: Present and Future

Couverture
Izet Kapetanović
BoD – Books on Demand, 16 déc. 2011 - 542 pages
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Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.
 

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Table des matières

Evolutionary Biology and Drug Development
25
Novel Oncology Drug Development
43
Drug Discovery into the 21st Century
69
Genetically Engineered Mouse Models
99
Genetic Pharmacotherapy
125
Critical Human HepatocyteBased In Vitro
151
The Use of In Vitro 3D Cell Models
169
Towards Understanding Drugs
231
Assessment of Cell Cycle Inhibitors
323
ImageBased HighContent
339
Recent Advances in Biotherapeutics
363
Drug Discovery by Aptamers
379
Streamlining ICH
391
Current
427
Silver Nanoparticles Universal Multifunctional
463
Mesenchymal Stem Cells
472

DeRisking Drug Discovery
275
Novel Approach to High Throughput
295

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