Statistical Methods in Environmental Epidemiology

Couverture
Oxford University Press, 2009 - 432 pages
Environmental epidemiology is the study of the environmental causes of disease in populations and how these risks vary in relation to intensity and duration of exposure and other factors like genetic susceptibility. As such, it is the basic science upon which governmental safety standards and compensation policies for environmental and occupational exposure are based. Profusely illustrated with examples from the epidemiologic literature on ionizing radiation and air pollution, thistext provides a systematic treatment of the statistical challenges that arise in environmental health studies and the use epidemiologic data in formulating public policy, at a level suitable for graduate students and epidemiologic researchers.After a general overview of study design and statistical methods for epidemiology generally, the book goes on to address the problems that are unique to environmental health studies, special-purpose designs like two-phase case-control studies and countermatching, statistical methods for modeling exposure-time-response relationships, longitudinal and time-series studies, spatial and ecologic methods, exposure measurement error, interactions, and mechanistic models. It also discusses studiesaimed at evaluating the public health benefits of interventions to improve the environment, the use of epidemiologic data to establish environmental safety standards and compensation policy, and concludes with emerging problems in reproductive epidemiology, natural and man-made disasters like globalwarming, and the global burden of environmentally caused disease. No other book provides such a broad perspective on the methodological challenges in this field at a level accessible to both epidemiologists and statisticians.
 

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Table des matières

1 A tale of two exposures
1
2 Basic epidemiologic study designs
19
3 Basic statistical methods
33
4 Multivariate models
55
5 Some specialpurpose designs
92
6 Modeling exposuretimeresponse relationships
110
7 Longitudinal models
139
8 Timeseries models for acute effects
158
11 Measurement error and exposure models
221
12 Multiple risk factors and interactions
258
13 Mechanistic models
279
14 Intervention studies
301
15 Risk assessment
320
16 Probability of causation and compensation
337
17 Further challenges
351
References
368

9 Spatial models
176
10 Ecologic inference
202

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À propos de l'auteur (2009)


Dr. Thomas is Professor of Preventive Medicine, Director of the Biostatistics Division, and Verna R. Richter Chair in Cancer Research at the University of Southern California Keck School of Medicine. He received his undergraduate degree from Haverford College, an M.S. in Mathematics from Stanford University, and a Ph.D. in Epidemiology and Biostatistics from McGill University in 1976. His primary research interest has been in the development of statistical methods in epidemiology, both environmental and genetic. He was a member of President Clinton's Advisory Committee on Human Radiation Experiments, as well as the National Academy of Sciences Committee on the Biological Effects of Ionizing Radiation (BEIR V), and radiation advisory committees for other governmental agencies. Dr. Thomas has many publications in statistical genetics, including the textbook Statistical Methods in Genetic Epidemiology (OUP, 2004), and is a past President of the International Genetic Epidiology Society.
Other books by the same author:
Statistical Methods in Genetic Epidemiology, 2004

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