The Biology of Alcoholism: Volume 3: Clinical Pathology

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Springer Science & Business Media, 9 mars 2013 - 674 pages
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In this volume, the third of our series, the emphasis has shifted from the theoretical and experimental to the more clinical and practical aspects of alcoholism. Where, in the earlier volumes, more attention was directed to animal than human studies, in this volume, almost all material deals with the human condition. The clinical manifestations of alcoholism may be divided into two major aspects, that of the disease itself and that of its complications. This separation is to some extent artificial since, in a sense, the natural history of the disease is a function of the development of certain complicating mechanisms. These mechanisms in turn either become part and parcel of the underlying condition -alcoholism-or give rise to a new set of clinical variables characterized as "medical complications. " At this point, the dichotomy becomes real. The disease alcoholism tends to be seen as a distinct psychosocial entity and to be treated with psychosocial techniques. The "medical complications" are more clearly envisioned as being within the legitimate domain of medical practice and are treated by physicians who often tend to ignore the underlying alcoholism. The "patient" is sometimes lost in between. The major thrust of this volume is an attempt to describe the mechanisms of alcoholism as they are now known, in such a way as to establish a continuum between the disease alcoholism and its "medical complications.
 

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Table des matières

Contents of Volume 1
1
Chapter
14
Chapter
16
The Natural History of Alcoholism
23
Chapter 7
25
References
32
Family Studies
38
Muscle
39
Summary
300
The Electroencephalogram in Chronic Alcoholics
302
Biochemistry of Gastrointestinal and Liver Diseases in Alcoholism
307
Intestinal Tract
309
Alcoholic Hepatitis
312
Experimental Studies of CNS Activity During Acute Administration
313
Alcoholic Cirrhosis
319
Pancreatitis
320

Animal Studies
45
Chapter 3
53
References
59
Enzymes
63
by Harold E Himwich and David A Callison
67
Studies of Expressive Behavior
68
Discussion and Conclusions
78
Predisposing and Preventive Factors
83
Enzymes of Acetaldehyde Metabolism
85
References
91
Selfstimulation Epileptiform Activity and Neuronal Activity
93
Summary and Conclusions
96
Family Structure in Alcoholism
98
Summary
102
Chapter 3
103
Alcoholism and Mortality
105
Alcoholism and Learning
106
Chapter 4
109
Pharmacological Considerations
110
The Interaction of Ethanol with the Congeners in Alcoholic Beverages
113
Discussion and Conclusions
117
Pathological Effects of LongTerm Alcohol Consumption
125
Effect of Ethanol on Neurohumoral Amine Metabolism
127
Serotonin
128
The Determinants of Alcohol Preference in Animals
131
Catecholamines
136
Biological Mechanisms in Alcohol Selection
137
Environmental Changes and Alcohol Preference
139
Tolerance and Cross Tolerance in Alcoholics and Other Drug Users
141
Acetylcholine
144
Cross Addiction Between Ethanol and Other Drugs
147
Alcohol and Traffic Accidents
150
Biochemical Factors in Selfselection of Alcohol
152
Acute Withdrawal from Alcohol 369
155
The Role of Acetaldehyde in the Actions of Ethanol
159
Conclusions
160
Chapter 5
163
Acetaldehyde Concentrations in Animals and Man 162
166
Voluntary Alcohol Consumption in Apes
169
Effect of Acetaldehyde on Biogenic Amine Release
174
Effects of Alcohol Consumption in Apes
175
Methyl Alcohol Intoxication
176
References
182
Chapter 5
183
Acetaldehyde and the DisulfiramEthanol Reaction
184
Overview
188
Chapter 6
191
Carbo
197
Properties of Drug Discriminability
198
Animal Dissociation Experiments
204
Influences of Alcohol on the Catabolic Phase of Carbohydrate Metabolism
205
Dissociation and the Alcoholic Blackout
210
Acute Alcoholism and Its Effects on Carbohydrate Metabolism
211
Implications for the Treatment of Alcoholism
212
Chronic Alcoholism and Its Effects on Carbohydrate Metabolism
218
Behavioral Studies of Alcoholism
219
Drinking Patterns
226
Chapter 7
229
Treatment of the Acute Withdrawal Syndrome
236
Nucleotides and Alcohol Metabolism
243
Porphyrins and Alcohol Metabolism
247
Summary
249
Summary
255
References
256
The Effects of Alcohol on Behavioral and Biological Factors
259
Chapter 8
263
Diseases of the Nervous System in Chronic Alcoholics
265
Chapter 1
266
Cerebellar Cortical Degeneration
272
Effects of Ethanol on the Endoplasmic Reticulum Microsomes
278
Central Pontine Myelinolysis
280
References
286
Pathogenesis and Prevention of the Alcoholic Fatty Liver
287
Chapter 10
289
Effects of Ethanol on Carbohydrate Metabolism
292
References
299
The Effects of LongTerm Administration on the Electroencephalogram
326
Chapter 10
327
References
330
Vitamin Deficiencies and Excesses in Alcoholism
334
Chapter 10
339
Effect of Alcoholism Ingestion Chronic and Acute on Vitamin
340
Changes in Cardiovascular Activity as a Function of Alcohol
341
Alcohol and the Central Circulation
347
References
350
Bile Secretion and Excretion
352
Alcohol and the Peripheral Circulation
357
Chapter 11
359
Acute Alcohol Intoxication
361
Pathogenesis
367
References
374
Summary
375
Clinical Features
376
Psychophysiological Studies of Human ANS
383
Zinc Metabolism in Alcoholism
386
Prognosis
389
References
391
References
393
Effects of Alcohol on Endocrine Function
401
Psychophysiological Studies of Alcohol Effect on the Human ANS
402
Chapter 12
403
Pulmonary Infections in Alcoholics
412
References
425
Miscellaneous Conditions Associated with Alcoholism
427
Effects of Endocrine Function on Alcoholism and Alcohol Metabolism
429
Chapter 13
435
Effects of Alcohol on Sleep
443
Nature of Cellular Injury
448
Neural Mechanisms of Sleep
451
Cardiomyopathy of Nutritional Deficiency
454
Sleep and the Biogenic Amines
459
Chapter 14
461
Alcohol and the Biogenic Amines
466
Vacuolization of Marrow Precursor Cells
467
The Nervous System
470
White Cell Abnormalities in Alcoholics
473
References
474
Chapter 15
481
The Blood
484
Introduction
485
Cancer of the Esophagus
490
Learning Principles and Research Relevant to Alcoholism
491
The Relationship of Alcohol to Other Cancers
495
Chapter 16
496
Evaluation
499
Alcohol Intolerance in Neoplastic Disease
505
Chapter 15
510
Chapter 16
513
Principal Nutritional Parameters
521
Alcohol and Aggression
525
Nutritionally Related Disorders in Alcoholism
534
Conclusion
540
Methods for the Determination of Ethanol and Acetaldehyde
545
Specific Procedures
551
Management of Alcoholic Malnutrition
552
Summary and Conclusions
559
Acetaldehyde Determinations
567
Chapter 17
575
Table Wines
581
Chapter 17
587
Dessert and Cocktail Wines
591
Alcoholics Anonymous
594
Variables in the Rehabilitation Model
596
The Alcoholic Personality
599
References
610
A Multivariant Treatment Model
633
Manpower Issues in Rehabilitation
643
Chapter 6
647
Index
659
Index 545
660
Identification of Unitary Mechanisms of Tolerance and Physical
661
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