Reducing, Refining and Replacing the Use of Animals in Toxicity Testing

David G. Allen, Dave Allen, Michael D.. Waters, Mike D. Waters
Royal Society of Chemistry, 2013 - 369 pages
This thought-provoking book describes the ever-expanding "toolbox" of methods now available to reduce, refine, or replace animal usage in toxicity testing.

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À propos de l'auteur (2013)

David G. Allen has over 10 years experience in molecular and cellular biology. This includes the evaluation of toxicological and pharmacological data for the Food and Drug Administration (FDA), and the identification and validation of alternative toxicological assays that reduce or replace animal usage in regulatory safety testing. He received is BSc and PhD from North Carolina State University in Raleigh, and his MSc from the University of North Carolina in Wilmington. Dr Allen is currently Director of the Environmental and Regulatory Sciences Division of Integrated Laboratory Systems in North Carolina. This involves responsibility for the evaluation of alternative toxicological methods and comprehensive environmental services for the Environmental Protection Agency and the State of Georgia. The role includes all aspects of divisional management such as staffing, budget projections, and business development. Michael D. Waters, holds a Ph.D. in Biochemistry from the University of North Carolina School of Medicine at Chapel Hill and a B.S. in Pre-medicine (Chemistry and Biology) from Davidson College. He is a former government scientist with more than 35 years of experience in research and research management positions at EPA and NIH/NIEHS and six years of private sector experience as Chief Scientific Officer at Integrated Laboratory Systems, Inc. His research interests have centered on the evaluation of chemically-induced mutations and altered molecular expression in the etiology of genetic disease. He is a widely-published scientist having published well over 100 peer-reviewed in authoritative international scientific journals. He has edited Mutation Research-Reviews for nearly 20 years and has held adjunct professorships at both the University of North Carolina and at Duke University for many years. He served as President of both the Environmental Mutagen Society and the International Association of Environmental Mutagen Societies (now the Environmental Mutagenesis and Genomics Society and the International Association of Environmental Mutagenesis and Genomics Societies, with more than seven thousand members worldwide). The databases he has developed and a number of his publications are recognized as important advances that have significantly impacted the fields of genetic toxicology, carcinogenesis, toxicogenomics, and risk assessment.

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