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CONTENTSPreface viiAcknowledgments ixList of Abbreviations xi1Basics of Metabolism and Pediatric Neurology ..............................................1Spectrum of Vitamin BCarbohydrate Metabolism: Inherited Muscle Glycogenosis 3Mitochondrial Metabolism 4Lipid Metabolism 5Purine Metabolism Disorders 6Peroxisomal Disorders 11Lysosomal Disorders: Sphingolipidoses 12Lysosomal Disorders: Mucopolysaccharidoses 14Porphyrias 15Dopamine and Catecholamine Metabolic Disorders 16Norepinephrine System 17Serotonin System 18Electrolyte Derangements 19Voltage-Gated Channels (Ionic Interaction) 24Gamma-Aminobutyric Acid 27Glutamate Receptors 28Autism Spectrum Disorders 29Attention-Defi cit Hyperactivity Disorder 30Floppy Infant Syndrome 31Microcephaly 33Macrocephaly 35Glutaric Aciduria Type I 36Biotinidase Defi ciency 37Mitochondrial Diseases 38Mitochondrial Encephalomyopathy Syndromes 39Maternally Inherited Leigh Syndrome and Related Disorders 40Primary White Matter Disorders 41Primary Gray Matter Disorders 43Symmetrical Bilateral Signal Abnormalities within the Basal Ganglia 44Angelman Syndrome 45Neurocutaneous Syndromes (Phakomatoses) 4612-Requiring Disorders 2 2Stroke, Migraine, and Epilepsy .........................................................................48Stroke 49Emergency Treatment of Ischemic Stroke 53Antiplatelet Drugs 54Carotid Endarterectomy 56Transient Ischemic Attack 57Subarachnoid Hemorrhage 58Intracerebral Hemorrhage 59Increased Intracranial Pressure 60Patent Foramen Ovale 61Neurovascular Syndromes 62Thalamic Syndromes 64CADASIL 70Important Stroke Mimickers 72Thrombotic Microangiopathies 74Disseminated Intravascular Coagulation 75Epilepsy 76Generalized Frontally Dominant Slow (3.5 Hz) Spike and Wave 77Centrotemporal Spikes and Waves 77Febrile Seizures 78Antiepileptic Agents 79Mechanisms of Action of AEDs 80Surgery for Epilepsy 82Status Epilepticus 83Epilepsy in Women 84Neonatal and Pediatric EEG 85Brainstem Auditory Evoked Potentials 87Visual Evoked Potentials 88Somatosensory Evoked Potentials 88Myoclonic Encephalopathies 90Atypical Progressive Myoclonic Encephalopathy 91Myoclonus and Renal Failure 92Epileptic Encephalopathies with Myoclonus 93Sleep Disorders 94Coma 98Persistent Vegetative State 99Brain Death 100Migraine and Other Headaches 101Selected Secondary Headaches 1073Infectious Diseases ..........................................................................................108Cerebrospinal Fluid 109Viral Encephalitis 111Imaging of Viral Encephalitis 112Aseptic Meningitis Syndrome 115Postencephalitic Parkinsonism 116HIV/AIDS-Related Infectious Disorders 117Neuroimaging of Abscesses 119Neurosyphilis 120Lyme Disease (Neuroborreliosis) 121Progressive Multifocal Leukoencephalopathy 122Parasitic Diseases of the Nervous System 123Neurosarcoidosis 125Whipple Disease 126Subacute Sclerosing Panencephalitis 127Prion Diseases 128Pathology of Infectious Diseases 130Pathology of Fungal Infections 131Pathology of Prion Diseases 1334Neurotoxicology ................................................................................................134Manganese Toxicity 135Botulism 136Nonbotulism Causes of Toxic Weakness 137Envenomations 138Lead Poisoning 139Mercury Intoxication 140Toxic Gases 142Toxic Solvents and Other Chemicals 143Marine Biotoxins 144Substance Abuse Disorders 145Alcohol and Sedatives Abuse and Withdrawal 146Alcoholism 147Psychostimulants: Cocaine and Amphetamine 150Marijuana, Hallucinogens, and PCP 151Opioids Intoxication and Withdrawal 152Toxic Leukoencephalopathies 153Neuroleptic Malignant Syndrome 1545Movement Disorders ........................................................................................155Cerebellar ataxias 155Inherited Ataxias with Identifi able Biochemical Errors 156Hereditary Ataxias: Autosomal Dominant Inheritance 157Episodic Ataxias 159Hereditary Ataxias: Autosomal Recessive Inheritance 160Hereditary Ataxias: X-Linked Inheritance 164Congenital Ataxic Disorders 166Acquired Ataxias: Selected Disorders 168Neurodegeneration with Brain Iron Accumulation 169Acanthocytosis-Related Neurologic Disorders 170Dystonia 171Parkinson Disease 178Imaging in Parkinson’s Disease and Other Parkinsonisms 180Levodopa-induced Dyskinesias 183Tremor in Conditions Other Than PD 187Progressive Supranuclear Palsy 189Multiple System Atrophy 191Autonomic Dysfunction in Neurodegenerative Diseases 193Corticobasal Degeneration 194Machado-Joseph Disease 195Other Parkinsonian Disorders 196Pathology of Tauopathies 198Pathology of Synucleinopathies 199Chorea 200Huntington Disease 201Sydenham Disease 202Restless Leg Syndrome (Ekbom Syndrome) 203Paroxysmal Dyskinesias 204Selected Facial Disorders 206Myoclonus 207Wilson Disease 208Tourette Syndrome 2096Behavioral Neurology ......................................................................................210Behavioral Neuroanatomy 211Amnesia 213Memory Primer 214Agnosias 215Apraxias 216Aphasias 217Acquired Dyslexia and Peripheral Dyslexia 218Neglect 219Delirium or Acute Confusional State 220Alzheimer’s Disease 221Mild Cognitive Impairment 224Vascular Dementia 225Dementia with Lewy Bodies (DLB) 226Frontotemporal Lobar Degeneration 227Focal Atrophy Syndromes in Dementias 229Frontal Assessment Battery (FAB): Offi ce Assessment of Frontal Function 2307Neuro-ophthalmology and Neuro-otology ...................................................231Transient Monocular Visual Loss 232Permanent Monocular Visual Loss 233Binocular Visual Loss 235Cerebral Visual Loss 236Anisocoria 237Diplopia 239Disorders of Saccades 241Nystagmus 242Selected Cerebellar, Pontine, and Midbrain Oculomotor Syndromes 244Giant-Cell Arteritis 245Tolosa-Hunt Syndrome 246Dizziness: Vertigo and Lightheadedness 247Benign Paroxysmal Positional Vertigo 248Ménière’s Disease 250Cerebellar Ataxia with Bilateral Vestibulopathy 2518Neural Tube Closure and Other Congenital Malformations .......................252Demyelinating Diseases, Neuro-oncology and Disorders ofMultiple Sclerosis 253Posterior Reversible Encephalopathy Syndrome 261Autoimmune Channelopathies 263Autoimmune Encephalopathies 264Brain Tumors 265Circumscribed Astrocytomas 266Diffuse Astrocytomas 267Oligodendrogliomas 268Ependymal Tumors 269Neuronal Tumors 270Mixed Ganglioneuronal Tumors 271Primitive Neuroectodermal Tumors 272Meningeal and Mesenchymal Tumors 273Primary Central Nervous System Lymphoma 274Pineal Tumors and Keratin-Containing Masses 275Paraneoplastic Syndromes of the CNS 277Paraneoplastic Syndromes of the PNS 278Disorders of Neural Tube Closure and Other Congenital Malformations 2809Neuromuscular Disorders ...............................................................................283Brachial Plexopathies 284Brachial Neuropathies 285Assessment of Hand Weakness 287Lumbar Plexus 288Sacral Plexus 288Tibial Nerve 289Peroneal Nerve 289Assessment of Foot Drop 290Guillain-Barré Syndrome 291Chronic Infl ammatory Demyelinating Polyneuropathy 292Myasthenia Gravis 293Amyotrophic Lateral Sclerosis (Motor Neuron Disease) 294Spinal Cord Pathologies per Compartment 297Neurogenic Bladder 299Axonal Polyneuropathies 301Complex Regional Pain Syndrome 303Neurogenic Orthostatic Hypotension 304Autosomal Dominant Recurrent Hereditary Neuropathies 305Paraproteinemic Neuropathies 308Multiple Myeloma 310Amyloid Neuropathies 311Peripheral Nerve Tumors 312Muscular Dystrophies: X-Linked Dystrophinopathies 313Limb-Girdle Muscular Dystrophies 314Congenital Muscular Dystrophies 315Distal Myopathies 316Myotonic Dystrophy 317Facioscapulohumeral Dystrophy 318Scapuloperoneal Dystrophy 318Oculopharyngeal Muscular Dystrophy 318Infl ammatory Myopathies 319Metabolic Myopathies 321Episodic Muscle Weakness 322Familial Periodic Paralysis: Clinical Recognition 323Progressive or Stable Muscle Weakness 324Mitochondrial Myopathies 325Other Myogenic Causes of Cramps and Myalgia 326Neurogenic Causes of Cramps and Myalgia 327Congenital Myopathies 328Malignant Hyperthermia Syndrome 329Critical Illness-Related Neuropathy and Myopathy 33010Psychiatry ...........................................................................................................331Depression 332Bipolar Disorder 335Anxiety Disorders 336Obsessive-Compulsive Disorder 338Personality Disorders 339Eating Disorders 340Schizophrenia and Other Psychoses 341Delusions 343Neuroleptic-Induced Movement Disorders 344Somatoform Disorders 345Dissociative Disorders 347Suggested References for Further Reading 348Index 359

Wolters Kluwer Health/Lippincott Williams & Wilkins

"Concise Neurology is to be used as a reference by neurologists and neurology trainees who have already learned about a topic, but want a quick yet thoughtful summary of key points. It can be particularly useful for novice or experienced neurologists held to time pressures"--Provided by publisher

Concise neurology