Myelin : basic and clinical advances
Kazunori Sango (Editor), Junji Yamauchi (Editor), Toru Ogata (Editor), Keiichiro Susuki (Editor)
This book presents the latest exciting advances in understanding of the structure and function of myelin in the central and peripheral nervous systems under normal and pathological conditions. Readers will find state of the art information from the perspectives of both basic neuroscience and clinical neurology and neuropathology. Detailed attention is paid to the findings and implications of recent research on the myelin-forming glial cells such as oligodendrocytes and Schwann cells. The discussion of myelin pathology encompasses a wide range of diseases and conditions, including, for example, multiple sclerosis, Pelizaeus-Merzbacher disease, traumatic brain and spinal cord injuries, brain tumors of glial cell origin, Charcot-Marie-Tooth disease, immune-mediated neuropathy, and diabetic neuropathy. The authors comprise researchers at the cutting edge of biotechnology and experts in the diseases discussed. The clearly written text is supported by numerous high-quality light and electron microscopy, CT, and MR images
Advances in experimental medicine and biology, v. 1190, volume 1190
Llibres electrònics
1 online resource (xi, 378 pages) : illustrations (some color)
9789813296367, 9813296364
1128881780
Print version:
Part 1. Myelination in neural development and regeneration
1. Cellular signal-regulated Schwann cell myelination and remyelination
2. Regulatory mechanism of peripheral nerve myelination by glutamate-induced signaling
3. Cytoskeletal signal-regulated oligodendrocyte myelination and remyelination
4. Activity-dependent myelination
5. Heterogeneity of oligodendrocytes and their precursor cells
Part 2. Specialized structures along the myelinated nerve fibers
6. Functional domains in myelinated axons
7. Physiology of myelinated nerve conduction and pathophysiology of demyelination
8. Under the ECM dome: the physiological role of the perinodal extracellular matrix as an ion diffusion barrier
9. Oligodendrocyte physiology modulating axonal excitability and nerve conduction
10. Mitochondrial dynamics in physiology and pathology of myelinated axons
11. The role of sulfatides in axon-glia interactions
12. Structures and molecular composition of Schmidt-Lanterman incisures
Part 3. Myelin pathology in the central nervous system
13. Pelizaeus-Merzbacher disease: molecular and cellular pathologies and associated phenotypes
14. Multiple sclerosis
15. Visualization of myelin for the diagnosis and treatment monitoring of multiple sclerosis
16. Roads to formation of normal myelin structure and pathological myelin structure
17. Therapeutic strategies for oligodendrocyte-mediated remyelination
18. Brain tumors of glial cell origin
Part 4. Myelin pathology in the peripheral nervous system
19. Schwann cell and the pathogenesis of Charcot-Marie-Tooth disease
20. Guillain- Barré Syndrome
21. Chronic inflammatory demyelinating polyneuropathy
22. Schwann cells as crucial players in diabetic neuropathy
23. Drug-induced demyelinating neuropathies
24. Transthyretin amyloid neuropathy: the Schwann cell hypothesis